Saint Anthony Church is centrally located, just south of downtown San Antonio, off Interstate 37 / Route 281. It is one mile west of the Alamodome and nearby the historic King William district.
From I-37 / Highway 281
Take the "Florida St / Carolina St" exit (140A). Proceed west on Florida to the first stop sign at South Presa. Turn left (south) on South Presa to the traffic light at Carolina. The Church is the red brick structure on your left (east). There is parking on Labor Street (also to your left) and Carolina Street. There are several off street parking spaces on the north side of the church. NOTE: Carolina and Florida Streets are parallel, one way streets running east and west.